Phosphatidic acid, phospholipase D and tumorigenesis
نویسندگان
چکیده
منابع مشابه
Phosphatidic acid, phospholipase D and tumorigenesis☆
Phospholipase D (PLD) is a membrane protein with a double role: maintenance of the structural integrity of cellular or intracellular membranes and involvement in cell signaling through the product of the catalytic reaction, PA, and through protein-protein interaction with a variety of partners. Cross-talk during PLD signaling occurs with other cancer regulators (Ras, PDGF, TGF and kinases). Ele...
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The activity of bacterial phospholipase D (PLD), a Ca-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Addition of other negatively charged lipids such as phosphatidylinositol, phosphatidylmethanol, and oleic acid either inhibited or had no effect on enzyme activity. Only negatively charged lipi...
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Phospholipase D (PLD) hydrolyzes membrane lipids to generate phosphatidic acid (PA) and a free-head group (Fig. 1), and this activity is widespread in plants. Recent results indicate that PLD plays multiple regulatory roles in diverse plant processes, including abscisic acid (ABA) signaling, programmed cell death, root hair patterning, root growth, freezing tolerance, and other stress responses...
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Phospholipase D (PLD) hydrolyzes membrane lipids to generate phosphatidic acid (PA) and a free-head group (Fig. 1), and this activity is widespread in plants. Recent results indicate that PLD plays multiple regulatory roles in diverse plant processes, including abscisic acid (ABA) signaling, programmed cell death, root hair patterning, root growth, freezing tolerance, and other stress responses...
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In mammalian cells, phospholipase D (PLD) and its product phosphatidic acid (PA) are involved in a number of signalling cascades, including cell proliferation, membrane trafficking and defence responses. In plant cells a signalling role for PLD and PA is also emerging. Plants have the extra ability to phosphorylate PA to produce diacylglycerol pyrophosphate (DGPP), a newly discovered phospholip...
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ژورنال
عنوان ژورنال: Advances in Biological Regulation
سال: 2014
ISSN: 2212-4926
DOI: 10.1016/j.jbior.2013.08.006